Dr. Guzmán Álvarez

DSC 0004 Guzmán ÁlvarezPosition: 

Profesor Adjunto DT

Affiliation: 

Laboratorio de Moléculas Bioactivas, CENUR Litoral Norte, Universidad de la República

Address: 

Estación Experimental “Dr. Mario A. Cassinoni”, Ruta 3 km 363, Paysandú, P.C. 60000 Uruguay. 

Full Telephone: 

+598 47227950, int ext 131

Email:

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Biography

He was born in 1986 in Montevideo Uruguay. Get his bachelor in biochemistry in 2009, and his Ph.D. in Medicinal Chemistry in 2012 both in Universidad de la República. Currently, he is working as Professor at Universidad de la República. He is the PI of the Bioactive Molecules Lab. The mind areas of expertise are infectious diseases in animal and human health. He wrote more than twenty research articles in drug discovery. He describes more than five molecules with successful results in animal models of the respective disease, such as Chagas, Leishmaniasis, and Fascioliasis. Other areas of research are antiviral drug development for HIV, RSV, Influenza, antineoplastic drug, acaricidal drug.

Publications:

  1. Florencia Ferraro, Ileana Corvo, Lucia Bergalli, Andrea Ilarraz, Mauricio Cabrera, Jorge Gil, Brian M. Susuki, Conor R. Caffrey, David J. Timson, Xavier Robert, Christophe Guillon, Teresa Freire, Guzmán Álvarez, Novel and Selective Inhibitors of Triosephosphate isomerase with anti-trematode activity. Sci Rep, 2020, 10, 2587 https://doi.org/10.1038/s41598-020-59460-y

  2. Elena Aguilera, Cintya Perdomo, Alejandra Espindola, Ileana Corvo, Paula Faral-Tello, Carlos Robello, Elva Serna, Fátima Benítez, Rocío Riveros, Susana Torres, Ninfa I. Vera de Bilbao, Gloria Yaluff, Guzmán Alvarez. A nature-inspired design yields a new class of steroids against tripanosomatids. Molecules 2019; 24(20). pii: E3800. doi: 10.3390/molecules24203800.

  3. Gaston Risi, Elena Aguilera, Enrique Lados, Gonzalo Suarez, Ines Carrera, Guzman Alvarez*, Gustavo Salinas* Caenorhabditis elegans infrared-based motility assay identified new hits for nematicide drug development. Vet Sci. 2019 Mar 17;6(1). pii: E29. doi: 10.3390/vetsci6010029.

  4. Fort RS, Trinidad Barnech JM, Dourron J, Colazzo M, Aguirre-Crespo FJ, Duhagon MA*, Guzmán Álvarez*. Isolation and Structural Characterization of Bioactive Molecules on Prostate Cancer from Mayan Traditional Medicinal Plants. Pharmaceuticals (Basel). 2018 Aug 14;11(3). pii: E78. doi: 10.3390/ph11030078.

  5. Natalia Sierra, Christelle Folio, Christophe Guillon*, Guzmán Álvarez* Looking for Novel Capsid Protein Multimerization Inhibitors of Feline Immunodeficiency Virus. Pharmaceuticals (Basel). 2018 Jul 10;11(3). pii: E67. doi: 10.3390/ph11030067.

  6. Saramago L, Gomes H, Alguilera E, Cerecetto H, González M, Cabrera M, Alzugaray MF, da Silva Vaz Junior I, Aguirre-López B, Cabrera N, Pérez-Montfort R, Merlino A, Moraes J*, Alvarez G*, Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity Vet. Sci. 2018, 5(3), 74; https://doi.org/10.3390/vetsci5030074

  7. Elena Aguilera, Guzmán Alvarez, Hugo Cerecetto, and Mercedes González. Polypharmacology in the treatment of Chagas disease. Current Topics in Medicinal Chemistry, 2018, doi: 10.2174/0929867325666180410101728.

  8. Aguilera E, Varela J, Serna E, Torres S, Yaluff G, Vera de Bilbao N, Cerecetto H, González M, Alvarez G. Looking for combination of benznidazole and T. cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment. Mem. Inst. Oswaldo Cruz, 2018, Rio de Janeiro: 1-8.

  9. Christelle Folio, Natalia Sierra, Marie Dujardin, Guzman Alvarez, and Christophe Guillon. Crystal Structure of the Full-Length Feline Immunodeficiency Virus Capsid Protein Shows an N-Terminal β-Hairpin in the Absence of N-Terminal Proline. ID: D_1200003758 and PDB ID: 5NA2, Viruses, 2017 9(11):335. doi: 10.3390/v9110335

  10. Guzmán Álvarez*, Cintya Perdomo, Cathia Coronel, Elena Aguilera, Javier Varela, Gonzalo Aparicio, Flavio R. Zolessi, Nallely Cabrera, Celeste Vega, Miriam Rolón, Antonieta Rojas De Arias, Ruy Pérez-Montfort, Hugo Cerecetto, Mercedes González. Multi-anti-parasitic activity of arylideneketones and thiazolidenehydrazines against Trypanosoma cruzi and Leishmania spp. Molecules 2017,22, 709.

  11. Rodríguez G, Nargoli J, López A, Moyna G, Álvarez G, Fernández M, Osorio-Martínez CA, González M, Cerecetto H. Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent. RSC Adv., 2017,7, 7983-7989.

  12. Aguilera E, Varela J, Birriel E, Serna E, Torres S, Yaluff G, Vera de Bilbao N, Aguirre-López B, Cabrera N, Díaz Mazariegos S, Tuena de Gómez-Puyou M, Gómez-Puyou A, Pérez-Montfort R, Minini L, Merlino A, Cerecetto H, González M, Alvarez G, Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity. ChemMedChem, 2016,11, 1328-1338.

  13. Couto M, Sánchez C, Dávila B, Machín V, Varela J, Álvarez G, Celano L, Aguirre-López B, Cabrera N, Tuena de Gómez-Puyou M, Gómez-Puyou A, Pérez-Montfort R, Cerecetto H, González, M. 3-H-[1,2]Dithiole as New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies, Molecules 2015, 20, 14595-14610.

  14. Minini L, González M, Cerecetto H, Álvarez G, Merlino A, Molecular docking and molecular dynamics simulation studies of Trypanosoma cruzi triosephosphate isomerase inhibitors. Insights into the inhibition mechanism and selectivity, J. Mol. Graph. Model, 2015. 58, 40-49.

  15. Álvarez G, Martínez, J., Varela J, Birriel E, Cruces E, Gabay M, Leal S, Escobar P, Serna E, Torres S, Yaluff G, Vera de Bilbao I, Aguirre-López B, Cabrera N, Tuena de Gómez-Puyou M, Gómez Puyou A, Pérez-Montfort R, Cerecetto H, Gonzalez M. Develop of bis-thiazoles as Trypanosoma cruzi triosephosphate isomerase inhibitors. Identification of new non-mutagenic in vivo active agents. Eur J Med Chem, 2015, 100, 246–256.

  16. Alvarez G, Varela J, Gabay M Leal S, Escobar P, Serna E, Torres S, Yaluff G, Vera de Bilbao I, Cerecetto H, Gonzalez M. Research and Development of Trypanosomicidal Drugs for Chagas Disease. XXIIII International Symposium on Medicinal Chemistry, Lisbon, Portugal, Book of Abstracts Wiley-VCH, ChemMedChem, 2014, pg 194. Link: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7187/homepage/2452_confs.html

  17. Lavaggi ML, Couto M, Ríos N, Ingold M, Croce F, Álvarez G, Cabrera M, López V, Cerecetto H, González M, Uso de seminarios experimentales como apoyo al primer curso teórico de Química Orgánica, Educación Química, 2014, 26, 202-211.

  18. Álvarez G, Varela J, Cruces E, Fernández M, Gabay M, Leal S, Escobar P, Serna E, Torres S, Sanabria L, Figueredo-Thiel S, Yaluff G, Vera de Bilbao I, Cerecetto H, Gonzalez M. Identification of New Amide Containing Thiazole as Drug Candidate for Treatment of Chagas' Disease, Antimicrob Agents Chemother. 2014, 59, 1398-1404.

  19. Alvarez G, Varela J, Márquez P, Gabay M, Arias R. C, Cuchilla, K, Echeverría G, Piro O, Chorilli M, Leal S, Escobar P, Serna E, Torres S, Yaluff G, Vera de Bilbao N, González M, Cerecetto H, Optimization of Anti-trypanosomatid Agents: Identification of Non-Mutagenic Drug Candidates with in vivo Activity, J Med Chem. 2014, 57, 3984-3999.

  20. Trochine A, Alvarez G, Corre S, Faral-Tello P, Durán R, Batthyany CI, González M, Cerecetto H, Robello C, Trypanosoma cruzi chemical proteomics using immobilized benznidazole, Exp Parasitol, 2014, 140C, 33-38.

 

Modificado por última vez enJueves, 24 Junio 2021 13:21

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